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Drug Name
Effexor (Venlafaxine)

Drug Uses
Effexor is a potent inhibitor of the reuptake of serotonin and norepinephrine-two neurotransmitters, thought to play important roles in the pathophysiology of depression. Correcting the imbalance of these two chemicals may help relieve symptoms of depression.

How Taken
Effexor comes as a capsule to take by mouth. It is usually taken once a day and should be taken with food. Each capsule should be swallowed whole with fluid and not divided, crushed, chewed, or placed in water, or it may be administered by carefully opening the capsule and sprinkling the entire contents on a spoonful of applesauce. This drug/food mixture should be swallowed immediately without chewing and followed with a glass of water to ensure complete swallowing of the pellets.

Drug Class and Mechanism
Venlafaxine is in a new class of anti-depressant medications that affects chemical messengers within the brain. These chemical messengers are called neurotransmitters, and some examples are serotonin, dopamine, and norepinephrine. Neurotransmitters are manufactured by nerve cells and are released by the cells. The neurotransmitters travel to nearby nerve cells and cause the cells to become more or less active. Many experts believe that an imbalance in these neurotransmitters is the cause of depression and also may play a role in anxiety. Venlafaxine is believed to work by inhibiting the release or affecting the action of these neurotransmitters. Venlafaxine is available in an extended release formulation (Effexor XR).

Missed Dose
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next one as directed. Do not take a double dose of this medication.

Storage
Store Effexor at room temperature (68F to 77F or 20C to 25C). Keep Effexor away from children.

Warnings/Precautions
Before starting Effexor, tell your doctor about any medicines you're taking, including over-the-counter drugs and herbal supplements. If you take MAOIs, you should not take Effexor. If you are taking antidepressants, you should be watched closely for signs that your condition is getting worse or that you are becoming suicidal, especially when you first start therapy, or when your dose is increased or decreased. You should also be watched for becoming agitated, irritable, hostile, impulsive, or restless. Such symptoms should be reported to your doctor right away. Effexor may raise blood pressure in some patients, so blood pressure should be monitored regularly. When you suddenly stop using or quickly lower your daily dose of Effexor, discontinuation symptoms may occur. Talk to your doctor before discontinuing or reducing your dose of Effexor. Pregnant or nursing women shouldn't take any antidepressant without consulting their doctor. Until you see how Effexor affects you, be careful doing such activities as driving a car or operating machinery. Avoid drinking alcohol while taking Effexor.

Possible Side Effects
If you experience any of the following serious side effects, stop taking Effexor and contact your doctor immediately or seek emergency medical treatment: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); seizures; or an irregular heartbeat or severely high blood pressure (blurred vision, headache).Other, less serious side effects may be more likely to occur. Continue to take Effexor and talk to your doctor if you experience nausea, vomiting, upset stomach, abdominal pain, or loss of appetite or weight; dry mouth; drowsiness or dizziness; mild tremor, anxiety, or agitation; insomnia; abnormal dreams; sexual problems such as impotence, abnormal ejaculation, difficulty reaching orgasm, or decreased libido; sweating; yawning; or increase in blood cholesterol levels (detected by blood tests); Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

More Information
If you have any of the following serious side effects, stop taking venlafaxine and contact your doctor immediately or seek emergency medical treatment: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); low blood pressure (dizziness, weakness); high blood pressure (severe headache, blurred vision); fever or chills.Less serious side effects may be more likely to occur. Continue to take venlafaxine and talk to your doctor if you experience sweating; blurred vision; insomnia; weakness; nausea, vomiting, diarrhea, constipation; decreased sex drive, impotence, or difficulty having an orgasm; dry mouth; remor, nervousness, anxiety trouble concentrating; or changes in appetite or weight.Side effects, other than those listed here, may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.


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